This original work introduces DeepPolisher, a groundbreaking tool from Google Research that revolutionizes genome assembly. Leveraging a Transformer architecture, it precisely corrects base-level errors, dramatically enhancing accuracy by reducing overall errors by 50% and critical insertion/deletion errors by over 70%. This innovation significantly improves genomic reference quality, exemplified by its contribution to the Human Pangenome Reference, and is crucial for accurate gene identification and the diagnosis of genetic diseases, making high-quality genomics resources broadly accessible.